復(fù)旦大學(xué)附屬中山醫(yī)院胰腺外科是中國(guó)最早開展胰十二指腸切除手術(shù)的大型醫(yī)療中心之一。目前形成特色鮮明的 “以手術(shù)為中心的胰腺腫瘤綜合診治模式”，也打造了“開放-腹腔鏡-機(jī)器人”的全手術(shù)體系。2005年率先組織了國(guó)內(nèi)跨區(qū)域聯(lián)合的多學(xué)科診療，2023年建成全國(guó)首家“膽胰腫瘤肝轉(zhuǎn)移多學(xué)科聯(lián)合門診”。是中華醫(yī)學(xué)會(huì)外科學(xué)分會(huì)胰腺外科學(xué)組的副組長(zhǎng)單位，也是教育部重點(diǎn)學(xué)科和國(guó)家“211”工程重點(diǎn)科室。 2015年，中山胰腺外科集中全院優(yōu)勢(shì)學(xué)科，建成集醫(yī)教研為一體且多科室聯(lián)動(dòng)的“中山胰腺腫瘤中心”，并于2022年獲批成為國(guó)家癌癥中心首批“胰腺癌臨床質(zhì)控中心”，2024年?duì)款^主持了上海市胰腺手術(shù)的質(zhì)量控制檢查。科室先后承擔(dān)包括國(guó)家自然科學(xué)基金重大儀器項(xiàng)目、科技部重大專項(xiàng)在內(nèi)的國(guó)家級(jí)課題50余項(xiàng)；牽頭或參與國(guó)內(nèi)外多中心臨床研究超過30項(xiàng)；在國(guó)際著名外科學(xué)或腫瘤學(xué)期刊上發(fā)表SCI論文300余篇；獲得發(fā)明專利10余項(xiàng)。參與國(guó)內(nèi)幾乎所有胰腺腫瘤診治指南的撰寫，并于2023年作為中國(guó)大陸唯一單位參與制定晚期胰腺癌診治的國(guó)際專家共識(shí)。 作為國(guó)內(nèi)最大的胰腺腫瘤綜合診治中心之一，中山胰腺外科每年完成胰腺切除手術(shù)超過1,200例，開展胰腺腫瘤綜合診治超過20,000人次，形成以“肝-胰聯(lián)合切除（多器官聯(lián)合手術(shù)）”、“轉(zhuǎn)化后擴(kuò)大根治（變不能開為可開）”、“微創(chuàng)手術(shù)（精準(zhǔn)和保留器官功能）”以及“全周期管理”為主的學(xué)科特色。先后榮獲上海市醫(yī)學(xué)科技進(jìn)步一等獎(jiǎng)、二等獎(jiǎng)，2022年度廈門市醫(yī)療十大創(chuàng)新技術(shù)等，是國(guó)內(nèi)乃至國(guó)際領(lǐng)先的超大型胰腺腫瘤診治中心。
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1、Yin L, Pu N, Thompson E, Miao Y, Wolfgang C, Yu J. Improved Assessment of Response Status in Patients with Pancreatic Cancer Treated with Neoadjuvant Therapy using Somatic Mutations and Liquid Biopsy Analysis. Clin Cancer Res. 2021 Feb 1;27(3):740-748. doi: 10.1158/1078-0432.CCR-20-1746. Epub 2020 Oct 20. PMID: 33082211.
2、Yin H, Pu N, Chen Q, Zhang J, Zhao G, Xu X, Wang D, Kuang T, Jin D, Lou W, Wu W. Gut-derived lipopolysaccharide remodels tumoral microenvironment and synergizes with PD-L1 checkpoint blockade via TLR4/MyD88/AKT/NF-κB pathway in pancreatic cancer. Cell Death Dis. 2021 Oct 30;12(11):1033. doi: 10.1038/s41419-021-04293-4. PMID: 34718325; PMCID: PMC8557215.
3、Xiang XS, Li PC, Wang WQ, Liu L. Histone deacetylases: A novel class of therapeutic targets for pancreatic cancer. Biochim Biophys Acta Rev Cancer. 2022 Jan;1877(1):188676. doi: 10.1016/j.bbcan.2022.188676. Epub 2022 Jan 10. PMID: 35016922.
4、Xu ZH, Wang WQ, Liu L, Lou WH. A special subtype: Revealing the potential intervention and great value of KRAS wildtype pancreatic cancer. Biochim Biophys Acta Rev Cancer. 2022 Jul;1877(4):188751. doi: 10.1016/j.bbcan.2022.188751. Epub 2022 Jun 19. PMID: 35732240.
5、Chen Q, Yin H, Liu S, Shoucair S, Ding N, Ji Y, Zhang J, Wang D, Kuang T, Xu X, Yu J, Wu W, Pu N, Lou W. Prognostic value of tumor-associated N1/N2 neutrophil plasticity in patients following radical resection of pancreas ductal adenocarcinoma. J Immunother Cancer. 2022 Dec;10(12):e005798. doi: 10.1136/jitc-2022-005798. PMID: 36600557; PMCID: PMC9730407.
6、Chen Q, Yin H, He J, Xie Y, Wang W, Xu H, Zhang L, Shi C, Yu J, Wu W, Liu L, Pu N, Lou W. Tumor Microenvironment Responsive CD8+ T Cells and Myeloid-Derived Suppressor Cells to Trigger CD73 Inhibitor AB680-Based Synergistic Therapy for Pancreatic Cancer. Adv Sci (Weinh). 2023 Nov;10(33):e2302498. doi: 10.1002/advs.202302498. Epub 2023 Oct 22. PMID: 37867243; PMCID: PMC10667825.
7、An YF, Pu N, Jia JB, Wang WQ, Liu L. Therapeutic advances targeting tumor angiogenesis in pancreatic cancer: Current dilemmas and future directions. Biochim Biophys Acta Rev Cancer. 2023 Sep;1878(5):188958. doi: 10.1016/j.bbcan.2023.188958. Epub 2023 Jul 24. PMID: 37495194.
8、Pu N, Wu W, Liu S, Xie Y, Yin H, Chen Q, He T, Xu Z, Wang W, Yu J, Liu L, Lou W. Survival benefit and impact of adjuvant chemotherapy following systemic neoadjuvant chemotherapy in patients with resected pancreas ductal adenocarcinoma: a retrospective cohort study. Int J Surg. 2023 Oct 1;109(10):3137-3146. doi: 10.1097/JS9.0000000000000589. PMID: 37418574; PMCID: PMC10583928.
9、Liu S, Wu W, Du Y, Yin H, Chen Q, Yu W, Wang W, Yu J, Liu L, Lou W, Pu N. The evolution and heterogeneity of neutrophils in cancers: origins, subsets, functions, orchestrations and clinical applications. Mol Cancer. 2023 Sep 7;22(1):148. doi: 10.1186/s12943-023-01843-6. PMID: 37679744; PMCID: PMC10483725.
10、Xu ZJ, Li JA, Cao ZY, Xu HX, Ying Y, Xu ZH, Liu RJ, Guo Y, Zhang ZX, Wang WQ, Liu L. Construction of S100 family members prognosis prediction model and analysis of immune microenvironment landscape at single-cell level in pancreatic adenocarcinoma: a tumor marker prognostic study. Int J Surg. 2024 Jun 1;110(6):3591-3605. doi: 10.1097/JS9.0000000000001293. PMID: 38498399; PMCID: PMC11175822.
11、Chen Q, Yin H, Jiang Z, He T, Xie Y, Mao W, Han J, Liu S, Lou W, Wu W, Habib JR, Yu J, Liu L, Pu N. Poor clinical outcomes and immunoevasive contexture in CD161+CD8+ T cells barren human pancreatic cancer. J Immunother Cancer. 2024 Mar 26;12(3):e008694. doi: 10.1136/jitc-2023-008694. PMID: 38531664; PMCID: PMC10966787.